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How Free Cationic Polymer Chains Promote Gene Transfection
Yue Yanan
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Description for How Free Cationic Polymer Chains Promote Gene Transfection
Paperback. Series: Springer Theses. Num Pages: 112 pages, 7 black & white illustrations, 38 colour illustrations, biography. BIC Classification: PNNP; PSB. Category: (G) General (US: Trade). Dimension: 235 x 155 x 6. Weight in Grams: 186.
In this PhD thesis, Yue Yanan addresses a long-overlooked and critical question in the development of non-viral vectors for gene delivery. The author determines that those uncomplexed and cationic polymer chains free in the solution mixture of polymer and DNA facilitate and promote gene transfection. Furthermore, by using a combination of synthetic chemistry, polymer physics and molecular biology, Yue confirms that it is those cationic polymer chains free in the solution mixture, rather than those bound to DNA chains, that play a decisive role in intracellular trafficking. Instead of the previously proposed and widely accepted “proton sponge” model, the author's ... Read more
In this PhD thesis, Yue Yanan addresses a long-overlooked and critical question in the development of non-viral vectors for gene delivery. The author determines that those uncomplexed and cationic polymer chains free in the solution mixture of polymer and DNA facilitate and promote gene transfection. Furthermore, by using a combination of synthetic chemistry, polymer physics and molecular biology, Yue confirms that it is those cationic polymer chains free in the solution mixture, rather than those bound to DNA chains, that play a decisive role in intracellular trafficking. Instead of the previously proposed and widely accepted “proton sponge” model, the author's ... Read more
Product Details
Format
Paperback
Publication date
2016
Publisher
Springer International Publishing AG Switzerland
Number of pages
112
Condition
New
Series
Springer Theses
Number of Pages
94
Place of Publication
Cham, Switzerland
ISBN
9783319343785
SKU
V9783319343785
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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