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DNA Methylation, Epigenetics and Metastasis
Manel . Ed(S): Esteller
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Description for DNA Methylation, Epigenetics and Metastasis
Hardback. Provides an outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. This book describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. Editor(s): Esteller, Manel. Series: Cancer Metastasis - Biology and Treatment. Num Pages: 310 pages, biography. BIC Classification: PSD. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 19. Weight in Grams: 631.
Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the ... Read more
Most of the cancer patients die because the tumoral cells do not "stick" in the original site, but instead detach, invade and disseminate throughout the bloodstream to distal sites, where these transformed cells start to proliferate and destroy again. In the last ten years, researchers have identified a number of important genes involved in these processes, including cadherins, laminins, heparan sulfates, inhibitors of proteases and angiogenesis and many others. The puzzling problem was that few genetic alterations in these genes had been described in human tumors, despite the common finding of down-regulation. CpG island hypermethylation-associated silencing has come to the ... Read more
Product Details
Format
Hardback
Publication date
2005
Publisher
Springer-Verlag New York Inc. United States
Number of pages
310
Condition
New
Series
Cancer Metastasis - Biology and Treatment
Number of Pages
310
Place of Publication
New York, NY, United States
ISBN
9781402036415
SKU
V9781402036415
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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