Telomerases: Chemistry, Biology, and Clinical Applications
Neal Lue
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Description for Telomerases: Chemistry, Biology, and Clinical Applications
Hardcover. This book gives biochemists, geneticists, and related investigators a comprehensive and up-to-date review and evaluation of telomerase research, a key subfield in understanding genetic function and diseases. Chapters cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Num Pages: 318 pages, Illustrations. BIC Classification: PN; PSBZ. Category: (P) Professional & Vocational. Dimension: 236 x 162 x 22. Weight in Grams: 612.
This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.
This book is a comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.
Product Details
Format
Hardback
Publication date
2012
Publisher
John Wiley & Sons Inc United Kingdom
Number of pages
318
Condition
New
Number of Pages
318
Place of Publication
New York, United States
ISBN
9780470592045
SKU
V9780470592045
Shipping Time
Usually ships in 7 to 11 working days
Ref
99-50
About Neal Lue
NEAL F. LUE, MD, PHD, is Professor in the Department of Microbiology and Immunology at Weill Cornell Medical College. He received his BS from Johns Hopkins University and his MD and PhD from Stanford University. His laboratory studies the structures and mechanisms of the telomere and telomerase complexes in a variety of fungal model systems. CHANTAL AUTEXIER, PHD, ... Read more
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