The BRICHOS Domain. Its Proproteins and Functions.
Presto, Jenny; Johansson, Jan
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Description for The BRICHOS Domain. Its Proproteins and Functions.
Paperback. Series: SpringerBriefs in Molecular Science. Num Pages: 28 pages, 13 colour illustrations, 1 black & white tables, biography. BIC Classification: PSBC. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 3. Weight in Grams: 103.
This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similarities, lacks established physiological function(s) and is found about 10 distantly related pro-protein families, several of which are associated with human disease. In this work, the authors review the mechanism by which BRICHOS inhibits Aβ aggregation and examine recent results from in vivo experiments where BRICHOS inhibits Aβ aggregation and toxicity in Drosophila melanogaster. BRICHOS is one of nature´s (more specific) ways to ... Read more
This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similarities, lacks established physiological function(s) and is found about 10 distantly related pro-protein families, several of which are associated with human disease. In this work, the authors review the mechanism by which BRICHOS inhibits Aβ aggregation and examine recent results from in vivo experiments where BRICHOS inhibits Aβ aggregation and toxicity in Drosophila melanogaster. BRICHOS is one of nature´s (more specific) ways to ... Read more
Product Details
Format
Paperback
Publication date
2015
Publisher
Springer International Publishing AG Switzerland
Number of pages
28
Condition
New
Series
SpringerBriefs in Molecular Science
Number of Pages
28
Place of Publication
Cham, Switzerland
ISBN
9783319165639
SKU
V9783319165639
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About Presto, Jenny; Johansson, Jan
Jenny Presto obtained her PhD in Medical Biochemistry from Uppsala University in 2006, where she studied the biosynthesis of heparan sulfate. She did a postdoc at the Swedish University of Agricultural Sciences (SLU) in Uppsala, Sweden, studying the function of the BRICHOS domain as a chaperone for surfactant protein C. In 2011, Jenny moved to Karolinska Institutet, Center for ... Read more
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