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Innate Tolerance in the CNS
. Ed(S): Gidday, Jeffrey M.; Perez-Pinzon, Miguel A.; Zhang, John H.
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Description for Innate Tolerance in the CNS
Hardback. Examining the phenomenon of cerebral preconditioning, which uses mild stressful stimuli to help brain tissue adapt to later, more severe injury, this volume presents the fundamentals and will aid the development of pharmacological neuroprotection agents. Editor(s): Gidday, Jeffrey M.; Perez-Pinzon, Miguel A.; Zhang, John H. Series: Springer Series in Translational Stroke Research. Num Pages: 708 pages, 18 black & white tables, biography. BIC Classification: MJN. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 41. Weight in Grams: 1226.
Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for ... Read more
Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for ... Read more
Product Details
Format
Hardback
Publication date
2012
Publisher
Springer-Verlag New York Inc. United States
Number of pages
708
Condition
New
Series
Springer Series in Translational Stroke Research
Number of Pages
699
Place of Publication
New York, NY, United States
ISBN
9781441996947
SKU
V9781441996947
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About . Ed(S): Gidday, Jeffrey M.; Perez-Pinzon, Miguel A.; Zhang, John H.
Jeffrey M. Gidday PhD, Associate Professor of Neurosurgery at Washington University School of Medicine, has been working in the field of CNS preconditioning for 18 years, and has numerous publications on preconditioning-induced protection in the setting of several different cerebral and retinal pathologies. Miguel A. Perez-Pinzon PhD is Professor of Neurology/Neuroscience, Vice-Chair for Basic Science of Neurology at ... Read more
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