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Morphofunctional Aspects of Tumor Microcirculation
Domenico Ribatti
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Description for Morphofunctional Aspects of Tumor Microcirculation
Paperback. This book describes abnormalities in the blood vessels of tumors, identifying a number of specific tumor endothelial markers, as well as chromosomal abnormalities. Shows how these markers may be used to deliver drugs selectively to the tumor microvasculature. Num Pages: 128 pages, 9 black & white tables, biography. BIC Classification: MJCL; PSF. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 7. Weight in Grams: 209.
Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A ... Read more
Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A ... Read more
Product Details
Format
Paperback
Publication date
2014
Publisher
Springer Netherlands
Number of pages
128
Condition
New
Number of Pages
116
Place of Publication
Dordrecht, Netherlands
ISBN
9789401782043
SKU
V9789401782043
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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