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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
Stephen B. . Ed(S): Howell
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Description for Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
Paperback. Editor(s): Howell, Stephen B. Num Pages: 546 pages, biography. BIC Classification: MJCL; MJCM; PSB. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 28. Weight in Grams: 776.
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, ... Read more
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, ... Read more
Product Details
Format
Paperback
Publication date
2013
Publisher
Springer-Verlag New York Inc. United States
Number of pages
546
Condition
New
Number of Pages
546
Place of Publication
New York, United States
ISBN
9781489907400
SKU
V9781489907400
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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