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Retinoids
. Ed(S): Orfanos, C. E.; Braun-Falco, Otto; Farber, Eugene M.; Grupper, C.; Polano, M.K.; Schuppli, R.
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Description for Retinoids
Paperback. Proceedings of the International Dermatology Symposium (IDS), Berlin, October 13-15, 1980 Editor(s): Orfanos, C. E.; Braun-Falco, Otto; Farber, Eugene M.; Grupper, C.; Polano, M.K.; Schuppli, R. Num Pages: 530 pages, biography. BIC Classification: MJK. Category: (P) Professional & Vocational. Dimension: 244 x 170 x 28. Weight in Grams: 946.
With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels ... Read more
With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels ... Read more
Product Details
Format
Paperback
Publication date
2011
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
530
Condition
New
Number of Pages
530
Place of Publication
Berlin, Germany
ISBN
9783642680250
SKU
V9783642680250
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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