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The Orexin/hypocretin System. Physiology and Pathophysiology.
Nishino, Seiji; Sakurai, Takeshi
€ 236.05
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Description for The Orexin/hypocretin System. Physiology and Pathophysiology.
Hardback. The Orexin/Hypocretin System provides an overview of all the recent exciting discoveries in the field as well as new findings such as ligand replacement and gene therapies in the animal models of narcolepsy. Several contributions cover sleep and the multiple systems involved in its regulation. Series: Contemporary Clinical Neuroscience. Num Pages: 416 pages, 142 black & white illustrations, 9 colour illustrations, biography. BIC Classification: MJN. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 28. Weight in Grams: 1062.
Orexin/hypocretin research began in 1998, as a result of the discovery of a new hypothalamic neuropeptide. In 1999, it was found that mutations in the orexin/ hypocretin-related genes caused a sleep disorder (narcolepsy) in dogs and mice. These findings were soon followed by the discoveries of orexin/hypocretin ligand deficiency in human narcolepsy. The finding of the major pathophysiological mechanisms of human narcolepsy resulted in its reclassification as a neurological, not a psychiatric, disorder. The - portance of early diagnosis and initiation of treatment for human narcolepsy has been repeatedly emphasized because the disease typically starts around puberty (when social and ... Read more
Orexin/hypocretin research began in 1998, as a result of the discovery of a new hypothalamic neuropeptide. In 1999, it was found that mutations in the orexin/ hypocretin-related genes caused a sleep disorder (narcolepsy) in dogs and mice. These findings were soon followed by the discoveries of orexin/hypocretin ligand deficiency in human narcolepsy. The finding of the major pathophysiological mechanisms of human narcolepsy resulted in its reclassification as a neurological, not a psychiatric, disorder. The - portance of early diagnosis and initiation of treatment for human narcolepsy has been repeatedly emphasized because the disease typically starts around puberty (when social and ... Read more
Product Details
Format
Hardback
Publication date
2005
Publisher
Humana Press Inc. United States
Number of pages
416
Condition
New
Series
Contemporary Clinical Neuroscience
Number of Pages
416
Place of Publication
Totowa, NJ, United States
ISBN
9781588294449
SKU
V9781588294449
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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