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Trinucleotide Diseases and Instability
Ben A. . Ed(S): Oostra
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Description for Trinucleotide Diseases and Instability
Paperback. Editor(s): Oostra, Ben A. Series: Results and Problems in Cell Differentiation. Num Pages: 169 pages, 32 black & white illustrations, 6 black & white tables, biography. BIC Classification: MFN; MJA; MJN. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 9. Weight in Grams: 284.
Till recently, mutations in genes were described in textbooks as deletions or point mutations. These mutations can be inherited from a parent or they are de novo alterations. The discovery in 1991 that human disease can be caused by large-scale ex pansion of highly unstable trinucleotide repeats has elucidated a new mutation mechanism, heritable unstable DNA. In the subsequent years more then 10 such disease genes have been identified. All dynamic mutations have been iden tified in neurological disorders. There are ten possible trinucleotide repeats at the DNA level, but only 3 have been identified as being involved in human ... Read more
Till recently, mutations in genes were described in textbooks as deletions or point mutations. These mutations can be inherited from a parent or they are de novo alterations. The discovery in 1991 that human disease can be caused by large-scale ex pansion of highly unstable trinucleotide repeats has elucidated a new mutation mechanism, heritable unstable DNA. In the subsequent years more then 10 such disease genes have been identified. All dynamic mutations have been iden tified in neurological disorders. There are ten possible trinucleotide repeats at the DNA level, but only 3 have been identified as being involved in human ... Read more
Product Details
Format
Paperback
Publication date
2013
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
169
Condition
New
Series
Results and Problems in Cell Differentiation
Number of Pages
169
Place of Publication
Berlin, Germany
ISBN
9783662225653
SKU
V9783662225653
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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