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Novel Approaches to Selective Treatments of Human Solid Tumors: Laboratory and Clinical Correlation (Volume 339)
Youcef M. . Ed(S): Rustum
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Description for Novel Approaches to Selective Treatments of Human Solid Tumors: Laboratory and Clinical Correlation (Volume 339)
paperback. Editor(s): Rustum, Youcef M. Series: Advances in Experimental Medicine and Biology. Num Pages: 319 pages, biography. BIC Classification: MJCL; PST; PSV. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 17. Weight in Grams: 640.
The therapeutic efficacy of FUra has been attributed to its incorporation into cellular RNA and, to its inhibition of thymidylate synthase, leading to potent inhibition of DNA synthesis and DNA damage. Studies of cell lines in vitro and model systems in vivo have demonstrated that although mechanisms of sensitivity and resistance to FUra are multifactorial, in the presence of citrovorum factor (LV, CF, 5-formyltetrahydrofolate) the site of action of FUr a becomes predominantly the pronounced and prolonged inhibition of thymidylate synthase. This action is the result of stabilization of the covalent ternary complex between FdUMP, an active metabolite of FUr ... Read more
The therapeutic efficacy of FUra has been attributed to its incorporation into cellular RNA and, to its inhibition of thymidylate synthase, leading to potent inhibition of DNA synthesis and DNA damage. Studies of cell lines in vitro and model systems in vivo have demonstrated that although mechanisms of sensitivity and resistance to FUra are multifactorial, in the presence of citrovorum factor (LV, CF, 5-formyltetrahydrofolate) the site of action of FUr a becomes predominantly the pronounced and prolonged inhibition of thymidylate synthase. This action is the result of stabilization of the covalent ternary complex between FdUMP, an active metabolite of FUr ... Read more
Product Details
Format
Paperback
Publication date
2012
Publisher
Springer/Sci-Tech/Trade United States
Number of pages
319
Condition
New
Series
Advances in Experimental Medicine and Biology
Number of Pages
319
Place of Publication
New York, NY, United States
ISBN
9781461360605
SKU
V9781461360605
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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