Drug Delivery to the Brain
. Ed(S): Hammarlund-Udenaes, Margareta; de Lange, Elizabeth; Thorne, Robert G.
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Description for Drug Delivery to the Brain
Paperback. In this book, experts in the field describe the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. Editor(s): Hammarlund-Udenaes, Margareta; de Lange, Elizabeth; Thorne, Robert G. Series: AAPS Advances in the Pharmaceutical Sciences Series. Num Pages: 751 pages, 24 black & white illustrations, 126 colour illustrations, biography. BIC Classification: MBGR; TDCW. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 38. Weight in Grams: 1133.
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper ... Read more
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper ... Read more
Product Details
Format
Paperback
Publication date
2016
Publisher
Springer-Verlag New York Inc. United States
Number of pages
751
Condition
New
Series
AAPS Advances in the Pharmaceutical Sciences Series
Number of Pages
731
Place of Publication
New York, United States
ISBN
9781493943661
SKU
V9781493943661
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About . Ed(S): Hammarlund-Udenaes, Margareta; de Lange, Elizabeth; Thorne, Robert G.
Margareta Hammarlund-Udenaes (PhD) is a Professor in Pharmacokinetics and Pharmacodynamics (PKPD) at Uppsala University and the Head of the Translational PKPD Group. Her research is focused at studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, which has led to the development of new concepts and methods within the BBB transport area, focusing on unbound drug ... Read more
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