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Advances in Rapid Sex-Steroid Action
. Ed(S): Castoria, Gabriella; Migliaccio, Antimo
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Description for Advances in Rapid Sex-Steroid Action
Hardback. This book examines how rapid steroid actions not only impact disease development and response to conventional therapies for breast and prostate cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities. Editor(s): Castoria, Gabriella; Migliaccio, Antimo. Num Pages: 270 pages, biography. BIC Classification: MJCL; MJG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 20. Weight in Grams: 596.
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate ... Read more
Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate ... Read more
Product Details
Format
Hardback
Publication date
2011
Publisher
Springer-Verlag New York Inc. United States
Number of pages
270
Condition
New
Number of Pages
270
Place of Publication
New York, NY, United States
ISBN
9781461417637
SKU
V9781461417637
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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