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Antifolate Drugs in Cancer Therapy
Ann L. . Ed(S): Jackman
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Description for Antifolate Drugs in Cancer Therapy
Paperback. Editor(s): Jackman, Ann L. Series: Cancer Drug Discovery and Development. Num Pages: 456 pages, 13 black & white illustrations, biography. BIC Classification: MQP. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 24. Weight in Grams: 891.
Antifolates are an important class of anticancer drugs originally developed as anti leu- kemic agents, but now used, usually in combination with other drugs, for the treatment of a wide range of tumors, notably carcinomas of the head and neck, breast, germ cell tumors, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and osteogenic sar- comas. 5-Fluorouracil and its prodrugs also target, in part, the folate-dependent enzyme, thymidylate synthase. Furthermore, folate supplementation in the form of leucovorin, modulates 5-fluororuacil activity. 5-Fluorouracil is widely used in the treatment of colorectal and gastric cancer and in combination for other solid tumors such as breast and ... Read more
Antifolates are an important class of anticancer drugs originally developed as anti leu- kemic agents, but now used, usually in combination with other drugs, for the treatment of a wide range of tumors, notably carcinomas of the head and neck, breast, germ cell tumors, non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and osteogenic sar- comas. 5-Fluorouracil and its prodrugs also target, in part, the folate-dependent enzyme, thymidylate synthase. Furthermore, folate supplementation in the form of leucovorin, modulates 5-fluororuacil activity. 5-Fluorouracil is widely used in the treatment of colorectal and gastric cancer and in combination for other solid tumors such as breast and ... Read more
Product Details
Format
Paperback
Publication date
2013
Publisher
Humana Press Inc. United States
Number of pages
456
Condition
New
Series
Cancer Drug Discovery and Development
Number of Pages
456
Place of Publication
Totowa, NJ, United States
ISBN
9781475745214
SKU
V9781475745214
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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