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CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
. Ed(S): Kyewski, B. (Dkfz Heidelberg, Germany); Suri-Payer, Elisabeth (Dkfz Heidelberg, Germany)
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Description for CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential
Paperback. Editor(s): Kyewski, B. (DKFZ Heidelberg, Germany); Suri-Payer, Elisabeth (DKFZ Heidelberg, Germany). Series: Current Topics in Microbiology and Immunology. Num Pages: 344 pages, 6 black & white illustrations, 12 colour illustrations, 3 black & white tables, biography. BIC Classification: MJCM. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 18. Weight in Grams: 483.
The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituentsthuspreservingitsintegrity. Multiplemechanismsactinconcert to ensure self-tolerance. During intrathymic development, the nascent T cell repertoire is purged from autoreactive T cells via negative selection, a process also known as recessive tolerance. Ridding of self-reactivity, however,isnotcomplete,asattestedbythepresenceofself-reactiveTcells intheperipheralTcellrepertoire. Hence,additionaltolerancemechanisms, collectively referred to as dominant tolerance, have been postulated on theoreticalgrounds(seethechapterbyA. Coutinhoetal. inthisvolume)and experimentalprooffortheirexistencehadbeenrepeatedlyclaimedinthepast 40years. Whilesomeoftheseclaims,largelybasedoninvitroexperiments, laterfellintodisrepute(i. e. ,theinfamousCD8suppressorcellsexpressingI-J molecules),concurrent,butlesswellpublicizedstringsofresearch,provided unremitting evidence for dominant tolerance mechanisms. These include the postnatal thymectomy model pioneered by Nishizuka and Sakakura in 1969, the dominant tolerance model in ... Read more
The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituentsthuspreservingitsintegrity. Multiplemechanismsactinconcert to ensure self-tolerance. During intrathymic development, the nascent T cell repertoire is purged from autoreactive T cells via negative selection, a process also known as recessive tolerance. Ridding of self-reactivity, however,isnotcomplete,asattestedbythepresenceofself-reactiveTcells intheperipheralTcellrepertoire. Hence,additionaltolerancemechanisms, collectively referred to as dominant tolerance, have been postulated on theoreticalgrounds(seethechapterbyA. Coutinhoetal. inthisvolume)and experimentalprooffortheirexistencehadbeenrepeatedlyclaimedinthepast 40years. Whilesomeoftheseclaims,largelybasedoninvitroexperiments, laterfellintodisrepute(i. e. ,theinfamousCD8suppressorcellsexpressingI-J molecules),concurrent,butlesswellpublicizedstringsofresearch,provided unremitting evidence for dominant tolerance mechanisms. These include the postnatal thymectomy model pioneered by Nishizuka and Sakakura in 1969, the dominant tolerance model in ... Read more
Product Details
Format
Paperback
Publication date
2010
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
344
Condition
New
Series
Current Topics in Microbiology and Immunology
Number of Pages
332
Place of Publication
Berlin, Germany
ISBN
9783642063763
SKU
V9783642063763
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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