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Genome Instability in Cancer Development
Erich A. . Ed(S): Nigg
€ 186.06
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Description for Genome Instability in Cancer Development
Hardback. Reviews both genetic and biochemical data on the origin of genome instability and its impact on carcinogenesis. This book discusses DNA repair mechanisms and hereditary cancer syndromes, as well as checkpoint mechanisms operating to safeguard chromosome integrity during cell cycle progression. Editor(s): Nigg, Erich A. Series: Advances in Experimental Medicine and Biology. Num Pages: 512 pages, biography. BIC Classification: MJCL. Category: (P) Professional & Vocational. Dimension: 244 x 170 x 25. Weight in Grams: 1294.
Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” ... Read more
Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” ... Read more
Product Details
Format
Hardback
Publication date
2005
Publisher
Springer-Verlag New York Inc. United States
Number of pages
512
Condition
New
Series
Advances in Experimental Medicine and Biology
Number of Pages
512
Place of Publication
New York, NY, United States
ISBN
9781402037634
SKU
V9781402037634
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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