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Human Immunodeficiency Virus Reverse Transcriptase
Legrice
€ 195.37
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Description for Human Immunodeficiency Virus Reverse Transcriptase
Hardcover. This book covers coordination of RT-associated DNA polymerase and ribonuclease H activities, mechanisms of action and perspectives on NRTIs and NNRTIs, strategies for targeting the RT enzyme and mechanisms in HIV variability and development of drug resistance. Editor(s): LeGrice, Stuart F. J; Gotte, Matthias. Num Pages: 361 pages, biography. BIC Classification: MJCJ2. Category: (P) Professional & Vocational. Dimension: 241 x 164 x 25. Weight in Grams: 694.
The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. ... Read more
The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. ... Read more
Product Details
Format
Hardback
Publication date
2013
Publisher
Springer-Verlag New York Inc. United States
Number of pages
280
Condition
New
Number of Pages
361
Place of Publication
New York, NY, United States
ISBN
9781461472902
SKU
V9781461472902
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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