Mechanisms of Lymphocyte Activation and Immune Regulation
. Ed(S): Gupta, Sudhir; Alt, Frederick W.; Cooper, Max D.; Melchers, F.; Rajewsky, Klaus
€ 249.49
FREE Delivery in Ireland
Description for Mechanisms of Lymphocyte Activation and Immune Regulation
Hardback. Features the proceedings that highlight developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity. Editor(s): Gupta, Sudhir; Alt, Frederick W.; Cooper, Max D.; Melchers, F.; Rajewsky, Klaus. Series: Advances in Experimental Medicine and Biology. Num Pages: 208 pages, 44 black & white illustrations, 4 black & white tables, biography. BIC Classification: MJCM. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 12. Weight in Grams: 479.
In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role ... Read more
Show LessProduct Details
Format
Hardback
Publication date
2007
Publisher
Springer-Verlag New York Inc. United States
Number of pages
208
Condition
New
Series
Advances in Experimental Medicine and Biology
Number of Pages
198
Place of Publication
New York, NY, United States
ISBN
9780387465272
SKU
V9780387465272
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
Reviews for Mechanisms of Lymphocyte Activation and Immune Regulation