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Myeloid-Derived Suppressor Cells and Cancer (SpringerBriefs in Immunology)
Escors, David, Talmadge, James E., Breckpot, Karine, Van Ginderachter, Jo A., Kochan, Grazyna
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Description for Myeloid-Derived Suppressor Cells and Cancer (SpringerBriefs in Immunology)
Paperback. Series: Springerbriefs in Immunology. Num Pages: biography. BIC Classification: MJCL; PSF. Category: (P) Professional & Vocational. Dimension: 235 x 155. .
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical ... Read more
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical ... Read more
Product Details
Format
Paperback
Publication date
2016
Publisher
Springer
Condition
New
Series
SpringerBriefs in Immunology
Number of Pages
102
Place of Publication
Cham, Switzerland
ISBN
9783319268194
SKU
V9783319268194
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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