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N-Oxidation of Drugs: Biochemistry, pharmacology, toxicology
Hlavica, Peter E.; Damani, L. A.
€ 354.78
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Description for N-Oxidation of Drugs: Biochemistry, pharmacology, toxicology
hardcover. Reviewing the state-of-the-art in nitrogen xenobiochemistry, this volume covers N-oxidized products, the enzymology of N-oxidation, the reductions and conjugations of N-oxygenated compounds and the bioactivation of nitrogenous compounds and cell toxity. Num Pages: 487 pages, biography. BIC Classification: MMG. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 234 x 156 x 28. Weight in Grams: 890.
The metabolic N-oxidation ofnitrogenousxenobiotics has been reported tc occur in many biologicalsystems, in addition to mammaliantissues, and the mechanisms appear to differ in many respects from those involved in oxidative attack atcarbon centres. Theextensive useofnitrogen-containing compounds as pharmaceuticals and chemical intermediates can lead to exposure to alarge numberofthese agentsunderwidelyvaryingconditions. Biotransformation of these xenobiotics by N-oxidative pathways can effect detoxication, butequallywellcaninduceformation ofcytotoxicmetabolites or potential promutagens and procarcinogens. The substantial progress, in recent years, in our understanding ofthe biochemistry and toxicology of N- oxidation of nitrogenous structures has created a need for a synthesis of current knowledge. This book provides a wide-ranging ... Read more
The metabolic N-oxidation ofnitrogenousxenobiotics has been reported tc occur in many biologicalsystems, in addition to mammaliantissues, and the mechanisms appear to differ in many respects from those involved in oxidative attack atcarbon centres. Theextensive useofnitrogen-containing compounds as pharmaceuticals and chemical intermediates can lead to exposure to alarge numberofthese agentsunderwidelyvaryingconditions. Biotransformation of these xenobiotics by N-oxidative pathways can effect detoxication, butequallywellcaninduceformation ofcytotoxicmetabolites or potential promutagens and procarcinogens. The substantial progress, in recent years, in our understanding ofthe biochemistry and toxicology of N- oxidation of nitrogenous structures has created a need for a synthesis of current knowledge. This book provides a wide-ranging ... Read more
Product Details
Format
Hardback
Publication date
1991
Publisher
Springer United Kingdom
Number of pages
487
Condition
New
Number of Pages
487
Place of Publication
London, United Kingdom
ISBN
9780412360305
SKU
V9780412360305
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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