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Phosphodiesterase Methods and Protocols
Claire . Ed(S): Lugnier
€ 124.43
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Description for Phosphodiesterase Methods and Protocols
hardcover. Describes concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. These readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner. Editor(s): Lugnier, Claire. Series: Methods in Molecular Biology. Num Pages: 336 pages, 92 black & white illustrations, 1 colour illustrations, biography. BIC Classification: MMG. Category: (G) General (US: Trade); (P) Professional & Vocational. Dimension: 235 x 155 x 25. Weight in Grams: 734.
Adenosine 3 ,5 -cyclic monophosphate (cAMP) and guanosine 3 ,5 -cyclic monophosphate are ubiquitous nucleotides that have been described as the first and second messengers. In concert with intracellular calcium and IP3, they play a major role in the control of intracellular signaling, which orchestrates normal and pathophysiological responses. Downstream from the cyclic nucleotide synthesis by adenylyl and guanylyl cyclases, the multigenic family of cyclic nucleotide phosphodiesterases (PDEs), by specifically hydrolyzing cyclic nucleotides, controls cAMP and cGMP levels to maintain a basal state. Their critical role in intracellular sign- ing has recently designated them as new therapeutical targets. Several leading ... Read more
Adenosine 3 ,5 -cyclic monophosphate (cAMP) and guanosine 3 ,5 -cyclic monophosphate are ubiquitous nucleotides that have been described as the first and second messengers. In concert with intracellular calcium and IP3, they play a major role in the control of intracellular signaling, which orchestrates normal and pathophysiological responses. Downstream from the cyclic nucleotide synthesis by adenylyl and guanylyl cyclases, the multigenic family of cyclic nucleotide phosphodiesterases (PDEs), by specifically hydrolyzing cyclic nucleotides, controls cAMP and cGMP levels to maintain a basal state. Their critical role in intracellular sign- ing has recently designated them as new therapeutical targets. Several leading ... Read more
Product Details
Format
Hardback
Publication date
2005
Publisher
Humana Press Inc. United States
Number of pages
336
Condition
New
Series
Methods in Molecular Biology
Number of Pages
336
Place of Publication
Totowa, NJ, United States
ISBN
9781588293145
SKU
V9781588293145
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
Reviews for Phosphodiesterase Methods and Protocols
"...interesting and thought provoking, but technically challenging...excellent guide to current research techniques in the field of phosphodiesterase." - Doody's Health Sciences Book Review Journal