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Targeting the Wnt Pathway in Cancer
. Ed(S): Goss, Katherine H.; Kahn, Michael
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Description for Targeting the Wnt Pathway in Cancer
Hardback. This book provides an overview of the Wnt pathway as a therapeutic target for cancer and discusses the preclinical development of inhibitors directed to upstream and downstream components of the pathway. Editor(s): Goss, Katherine H.; Kahn, Michael. Num Pages: 240 pages, 4 black & white tables, biography. BIC Classification: MJCL; MMG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 18. Weight in Grams: 543.
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the ... Read more
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the ... Read more
Product Details
Format
Hardback
Publication date
2011
Publisher
Springer-Verlag New York Inc. United States
Number of pages
240
Condition
New
Number of Pages
240
Place of Publication
New York, NY, United States
ISBN
9781441980229
SKU
V9781441980229
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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