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The Molecular Biology of Pagets Disease
Paul T. . Ed(S): Sharpe
€ 66.82
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Description for The Molecular Biology of Pagets Disease
Paperback. Editor(s): Sharpe, Paul T. Series: Medical Intelligence Unit. Num Pages: 206 pages, 42 black & white illustrations, 5 black & white tables, biography. BIC Classification: MBGR. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 12. Weight in Grams: 434.
The osteoclasts in Paget's disease are abnormal both in num- ber and size and show nuclear inclusions as well as cytoplasmic inclusions that suggest a viral etiology for Paget's disease. Use of in vitro model systems for examining osteoclast physiology in Paget's disease has shown that these cells have an increased rate of formation, express high levels of IL-6, IL-6 receptor, and NF-IL-6, as well as most recently, the c-FOS protooncogene. 31 The precur- sors for these pagetic osteoclasts have several abnormalities includ- ing hyperresponsivity to 1,25-dihydroxyvitamin D , presence of 3 measles virus nucleocapsid transcripts, and hyperresponsivity to the ... Read more
The osteoclasts in Paget's disease are abnormal both in num- ber and size and show nuclear inclusions as well as cytoplasmic inclusions that suggest a viral etiology for Paget's disease. Use of in vitro model systems for examining osteoclast physiology in Paget's disease has shown that these cells have an increased rate of formation, express high levels of IL-6, IL-6 receptor, and NF-IL-6, as well as most recently, the c-FOS protooncogene. 31 The precur- sors for these pagetic osteoclasts have several abnormalities includ- ing hyperresponsivity to 1,25-dihydroxyvitamin D , presence of 3 measles virus nucleocapsid transcripts, and hyperresponsivity to the ... Read more
Product Details
Format
Paperback
Publication date
2013
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
206
Condition
New
Series
Medical Intelligence Unit
Number of Pages
206
Place of Publication
Berlin, Germany
ISBN
9783662225073
SKU
V9783662225073
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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