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Siegfried Kasper - Treatment-Resistant Depression - 9781119952909 - V9781119952909
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Treatment-Resistant Depression

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Description for Treatment-Resistant Depression Paperback. The first book devoted to a challenging disorder that affects millions of people around the world. Essential reading for all psychiatrists who manage these patients. . Editor(s): Kasper, Siegfried; Montgomery, Stuart A. Num Pages: 228 pages, Illustrations. BIC Classification: MJN. Category: (P) Professional & Vocational. Dimension: 128 x 200 x 11. Weight in Grams: 218.
Treatment-resistant Depress

Successful management of patients with treatment-resistant depression requires a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest scientific research and its applications in clinical practice.

A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes. The opening chapter reviews definitions and predictors of treatment-resistant depression originating from different fields and discusses their usefulness in clinical practice and clinical research. ... Read more

Biological classification requires identification of genetic risk factors and gene variants have been identified as accounting for 50% of the variance in the clinical outcomes of antidepressant treatments. Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, suggests that genetic prediction of treatment resistance could become a widespread clinical reality within a few years.

Most patients with treatment-resistant depression will be treated pharmacologically, so three chapters review the latest evidence for pharmacological best practice in switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium.

There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy. The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy. The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, explaining that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy. It proposes indications for psychotherapy in treatment-resistant depression and summarizes general therapeutic principles.

Essential reading for all psychiatrists managing patients with this distressing disorder.

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Product Details

Format
Paperback
Publication date
2013
Publisher
John Wiley and Sons Ltd
Number of pages
228
Condition
New
Number of Pages
228
Place of Publication
Hoboken, United Kingdom
ISBN
9781119952909
SKU
V9781119952909
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15

About Siegfried Kasper
Professor Dr Kasper is Professor of Psychiatry and Chairman of the Department of General Psychiatry at the Medical University of Vienna, Austria. He is Honorary Professor at the University of Hong Kong, China. He concentrates on the biological bases of mental disorders and their possible treatment approaches. He has conducted studies in psychopathological as well as clinical areas. Dr ... Read more

Reviews for Treatment-Resistant Depression
“After all, this book is recommended for the young psychiatrist, who wants to read an easy introduction to the fascinating world of treatment of resistant depression.”  (Acta Psychiatrica Scandinavica, 9 November 2013) “This is a monograph, which could be of great interest to psychiatrists managing patients with TRD. The chapters are written clearly, and the references are comprehensive ... Read more

Goodreads reviews for Treatment-Resistant Depression


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