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Receptors and Other Targets for Toxic Substances
. Ed(S): Chambers, P. L.; Cholnoky, E.; Chambers, C.
€ 131.10
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Description for Receptors and Other Targets for Toxic Substances
Paperback. Editor(s): Chambers, P. L.; Cholnoky, E.; Chambers, C. Series: Archives of Toxicology. Num Pages: 520 pages, 9 black & white illustrations, biography. BIC Classification: MMG; MQP; PSB. Category: (P) Professional & Vocational. Dimension: 244 x 170 x 27. Weight in Grams: 845.
Trichloroethylene (TRI), administered orally at high doses for 18 months has been shown to increase the incidence of hepatocellular carcinoma in B6C3F 1 mice but not Osborne-Mendel rats (NCI, 1976). The interpretation of these studies has been confounded due to the presence of epoxide stabilizers in the TRI. However more recent studies have demonstrated that pure TRI also causes hepatocellular carcinoma in B6C3F mice (NTP, 1983) and Aldedey Park (Swiss) mice (Elcombe 1 and Pratt, unpublished data). Furthermore, no increase in the incidence of hepatocellular carcinoma was observed in Fisher 344 rats administered pure TRI (NTP, 1983). TRI has been ... Read more
Trichloroethylene (TRI), administered orally at high doses for 18 months has been shown to increase the incidence of hepatocellular carcinoma in B6C3F 1 mice but not Osborne-Mendel rats (NCI, 1976). The interpretation of these studies has been confounded due to the presence of epoxide stabilizers in the TRI. However more recent studies have demonstrated that pure TRI also causes hepatocellular carcinoma in B6C3F mice (NTP, 1983) and Aldedey Park (Swiss) mice (Elcombe 1 and Pratt, unpublished data). Furthermore, no increase in the incidence of hepatocellular carcinoma was observed in Fisher 344 rats administered pure TRI (NTP, 1983). TRI has been ... Read more
Product Details
Format
Paperback
Publication date
1985
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
520
Condition
New
Series
Archives of Toxicology
Number of Pages
520
Place of Publication
Berlin, Germany
ISBN
9783540136705
SKU
V9783540136705
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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