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Peter . Ed(S): Scott - Linker Strategies in Solid-phase Organic Synthesis - 9780470511169 - V9780470511169
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Linker Strategies in Solid-phase Organic Synthesis

€ 288.46
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Description for Linker Strategies in Solid-phase Organic Synthesis Filling a gap in solid-phase literature, Linker Strategies in Solid-Phase Organic Synthesis guides readers through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting-edge diversity linker units defining a new era of solid-phase synthesis. Editor(s): Scott, Peter. Num Pages: 706 pages, Illustrations. BIC Classification: PNN. Category: (P) Professional & Vocational. Dimension: 251 x 193 x 44. Weight in Grams: 1486.
Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis.

Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis.  Individual linker classes are covered in easy to follow chapters written ... Read more

  • the principles of solid phase organic synthesis
  • electrophile and nucleophile cleavable linker units
  • cyclative cleavage as a solid phase strategy
  • photocleavable linker units
  • safety-catch linker units
  • enzyme cleavable linker units
  • T1 and T2 –versatile triazene linker groups
  • hydrazone linker units
  • benzotriazole linker units
  • phosphorus linker units
  • sulfur linker units
  • selenium and tellurium linker units
  • sulfur, oxygen and selenium linker units cleaved by radical processes
  • silicon and germanium linker units
  • boron and stannane linker units
  • bismuth linker units
  • transition metal carbonyl linker units
  • linkers releasing olefins or cycloolefins by ring-closing metathesis
  • fluorous linker units
  • solid-phase radiochemistry

The book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis.

Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.

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Product Details

Publication date
2009
Publisher
John Wiley and Sons Ltd United States
Number of pages
706
Condition
New
Number of Pages
706
Format
Hardback
Place of Publication
New York, United States
ISBN
9780470511169
SKU
V9780470511169
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15

About Peter . Ed(S): Scott
Dr Peter J. H. Scott, Department of Radiology, University of Michigan, Ann Arbor, USA Dr. Peter Scott has worked at Siemens Molecular Imaging and Biomarker Research where he was head of radiochemistry at the LA Tech Center and involved in the design and synthesis of novel radiopharmaceuticals for use in PET imaging. In April 2009 Dr. Scott joined the University ... Read more

Reviews for Linker Strategies in Solid-phase Organic Synthesis
"It is without a doubt an invaluable addition to any university or corporate library serving organic and biochemical researchers." (CHOICE, September 2010) "This book is a useful complement to literature reviews as well as other SPOS books. It will be a valuable resource for university libraries and an excellent first source for practitioners of solid-phase organic ... Read more

Goodreads reviews for Linker Strategies in Solid-phase Organic Synthesis


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