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Acute Neuronal Injury
Denson G. . Ed(S): Fujikawa
€ 270.01
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Description for Acute Neuronal Injury
Paperback. This book sets out to explain the clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death. Editor(s): Fujikawa, Denson G. Num Pages: 318 pages, biography. BIC Classification: MJN; MMF; MMH; PSAN; PSF. Category: (G) General (US: Trade). Dimension: 235 x 155 x 17. Weight in Grams: 492.
Denson G. Fujikawa 2+ In the early 1980s it was recognized that excessive Ca influx, presumably through 2+ 2+ voltage-gated Ca channels, with a resultant increase in intracellular Ca , was associated with neuronal death from cerebral ischemia, hypoglycemia, and status epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, generating free radicals, was thought to be a potential mechanism by which neuronal damage occurs. In cerebral ischemia and 2+ hypoglycemia, energy failure was thought to be the reason for excessive Ca influx, whereas in status epilepticus it was thought that repetitive depolarizations were responsible ... Read more
Denson G. Fujikawa 2+ In the early 1980s it was recognized that excessive Ca influx, presumably through 2+ 2+ voltage-gated Ca channels, with a resultant increase in intracellular Ca , was associated with neuronal death from cerebral ischemia, hypoglycemia, and status epilepticus (Siejo 1981). Calcium activation of phospholipases, with arachidonic acid accumulation and its oxidation, generating free radicals, was thought to be a potential mechanism by which neuronal damage occurs. In cerebral ischemia and 2+ hypoglycemia, energy failure was thought to be the reason for excessive Ca influx, whereas in status epilepticus it was thought that repetitive depolarizations were responsible ... Read more
Product Details
Format
Paperback
Publication date
2014
Publisher
Springer-Verlag New York Inc. United States
Number of pages
318
Condition
New
Number of Pages
306
Place of Publication
New York, United States
ISBN
9781489982858
SKU
V9781489982858
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About Denson G. . Ed(S): Fujikawa
Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with ... Read more
Reviews for Acute Neuronal Injury
“This is an outstanding book concerning the molecular and cellular mechanisms of trauma and ischemia in the mammalian brain. … I recommend his book to neurophysiologists, neurologists, and neurosurgeons.” (Joseph J. Grenier, Amazon.com, September, 2015)