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Chuang Lu - Enzyme Inhibition in Drug Discovery and Development - 9780470281741 - V9780470281741
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Enzyme Inhibition in Drug Discovery and Development

€ 247.90
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Description for Enzyme Inhibition in Drug Discovery and Development Hardcover. This book covers the science and approaches of enzyme inhibition applied in drug discovery and drug development, including both pharmacology and pharmacokinetic aspects of enzyme inhibition. Editor(s): Lu, Chuang; Li, Albert P. Num Pages: 868 pages, Illustrations. BIC Classification: MJ; MMG; PN. Category: (P) Professional & Vocational. Dimension: 244 x 167 x 44. Weight in Grams: 1324.
The science and applied approaches of enzyme inhibition in drug discovery and development

Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.

With chapters written by over fifty leading experts in their fields, Enzyme Inhibition in Drug Discovery and Development fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the "good" inhibitions—desirable pharmacological effects—and "bad" inhibitions—drug–drug interactions and toxicity. The book discusses:

  • The ... Read more

  • The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions

  • The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway

Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.

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Product Details

Format
Hardback
Publication date
2010
Publisher
John Wiley and Sons Ltd United Kingdom
Number of pages
868
Condition
New
Number of Pages
868
Place of Publication
New York, United States
ISBN
9780470281741
SKU
V9780470281741
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15

About Chuang Lu
Chuang Lu, PhD, is the Associate Director in the Drug Safety and Disposition Department of Millennium Pharmaceuticals. His current research interests include drug-metabolizing enzymes, drug–drug interaction, and in vitro–in vivo correlation. Albert P. Li, PhD, is the President and CEO of In Vitro ADMET Laboratories, LLC and Advanced Pharmaceutical Sciences, Inc., and the cofounder, Chairman, and CSO of the ... Read more

Reviews for Enzyme Inhibition in Drug Discovery and Development
"The description of each topic is clear, well organized and informative, making the book a useful or even essential high-level handbook." (ChemMedChem, November 2010)

Goodreads reviews for Enzyme Inhibition in Drug Discovery and Development


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