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Extrasynaptic GABAA Receptors
. Ed(S): Di Giovanni, Giuseppe; Errington, Adam C.; Crunelli, Vincenzo
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Description for Extrasynaptic GABAA Receptors
Paperback. Editor(s): Di Giovanni, Giuseppe; Errington, Adam C.; Crunelli, Vincenzo. Series: The Receptors. Num Pages: 304 pages, 16 black & white illustrations, 18 colour illustrations, 5 black & white tables, biograph. BIC Classification: MJN; MMG; PSAN. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 17. Weight in Grams: 474.
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant ... Read more
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant ... Read more
Product Details
Format
Paperback
Publication date
2016
Publisher
Springer-Verlag New York Inc. United States
Number of pages
304
Condition
New
Series
The Receptors
Number of Pages
295
Place of Publication
New York, United States
ISBN
9781493953219
SKU
V9781493953219
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
Reviews for Extrasynaptic GABAA Receptors
“This is an excellent monograph on the subject of GABA neurotransmission and GABA receptors in the synaptic and postsynaptic regions. … I highly recommend this book for neuroscientists, and neurophysiologists in an academic setting. It is of use for students, fellows, and postdoctoral scholars.” (Joseph J. Grenier, Amazon.com, May, 2015)