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Folyl and Antifolyl Polyglutamates
I. David . Ed(S): Goldman
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Description for Folyl and Antifolyl Polyglutamates
Paperback. Editor(s): Goldman, I. David. Series: Advances in Experimental Medicine and Biology. Num Pages: 425 pages, biography. BIC Classification: MMG. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 23. Weight in Grams: 824.
The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com pounds are not only the forms of folate co-factors that accumulate within cells, but, in addition, are the preferred substrates for folate dependent reactions in eukaryotic cells. More recently attention has turned to the potential importance of the polyglutamyl derivatives of methotrexate that have been detected in normal and malignant cells both in vitro and in vivo. The biochemical trans formation of this important chemotherapeutic agent is of particular significance since polyglutamyl derivatives of methotrexate are not only potent inhibitors of the target ... Read more
The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com pounds are not only the forms of folate co-factors that accumulate within cells, but, in addition, are the preferred substrates for folate dependent reactions in eukaryotic cells. More recently attention has turned to the potential importance of the polyglutamyl derivatives of methotrexate that have been detected in normal and malignant cells both in vitro and in vivo. The biochemical trans formation of this important chemotherapeutic agent is of particular significance since polyglutamyl derivatives of methotrexate are not only potent inhibitors of the target ... Read more
Product Details
Format
Paperback
Publication date
2013
Publisher
Springer-Verlag New York Inc. United States
Number of pages
425
Condition
New
Series
Advances in Experimental Medicine and Biology
Number of Pages
425
Place of Publication
New York, NY, United States
ISBN
9781475752434
SKU
V9781475752434
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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