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New Targets in Inflammation
. Ed(S): Bazan, Nicolas G.; Botting, Jack H.; Vane, Sir John R.
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Description for New Targets in Inflammation
Paperback. Editor(s): Bazan, Nicolas G.; Botting, Jack H.; Vane, Sir John R. Num Pages: 147 pages, biography. BIC Classification: MMG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 9. Weight in Grams: 260.
For the past 100 years the mainstay of therapy for rheumatoid arthritis (RA) has been aspirin or other drugs of the non-steroid anti-inflammatory group. In 1971 Vane pro posed that both the beneficial and toxic actions of these drugs was through inhibition of prostaglandin synthesis. The recent discovery that prostaglandins responsible for pain and other symptoms at inflammatory foci are synthesized by an inducible cyclooxygenase (COX-2) that is encoded by a gene distinct from that of the consti tutive enzyme (COX-I) provided a new target for therapy of RA. A drug that would selectively inhibit COX-2 would hopefully produce the ... Read more
For the past 100 years the mainstay of therapy for rheumatoid arthritis (RA) has been aspirin or other drugs of the non-steroid anti-inflammatory group. In 1971 Vane pro posed that both the beneficial and toxic actions of these drugs was through inhibition of prostaglandin synthesis. The recent discovery that prostaglandins responsible for pain and other symptoms at inflammatory foci are synthesized by an inducible cyclooxygenase (COX-2) that is encoded by a gene distinct from that of the consti tutive enzyme (COX-I) provided a new target for therapy of RA. A drug that would selectively inhibit COX-2 would hopefully produce the ... Read more
Product Details
Format
Paperback
Publication date
2012
Publisher
Springer Netherlands
Number of pages
147
Condition
New
Number of Pages
147
Place of Publication
Dordrecht, Netherlands
ISBN
9789401062657
SKU
V9789401062657
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About . Ed(S): Bazan, Nicolas G.; Botting, Jack H.; Vane, Sir John R.
Jack Botting is Consultant at the William Harvey Research Institute, an independent charitable foundation within Queen Mary and Westfield College of the University of London, UK. Sir John Vane is the Director General at the William Harvey Research Institute, an independent charitable foundation within Queen Mary and Westfield College of the University of London, UK. Sir ... Read more
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