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Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
. Ed(S): Clemmesen, Johannes; Conning, D. M.; Henschler, D.; Oesch, Franz
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Description for Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
Paperback. Editor(s): Clemmesen, Johannes; Conning, D. M.; Henschler, D.; Oesch, Franz. Series: Archives of Toxicology. Num Pages: 338 pages, 5 black & white illustrations, biography. BIC Classification: MMG. Category: (P) Professional & Vocational. Dimension: 244 x 170 x 18. Weight in Grams: 556.
N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. , 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al- kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least ... Read more
N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. , 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al- kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least ... Read more
Product Details
Format
Paperback
Publication date
1980
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
338
Condition
New
Series
Archives of Toxicology
Number of Pages
338
Place of Publication
Berlin, Germany
ISBN
9783540095842
SKU
V9783540095842
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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