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Selective COX-2 Inhibitors
. Ed(S): Vane, Sir John R.; Botting, Jack H.
€ 126.58
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Description for Selective COX-2 Inhibitors
Paperback. Editor(s): Vane, Sir John R.; Botting, Jack H. Num Pages: 150 pages, biography. BIC Classification: MMG. Category: (P) Professional & Vocational. Dimension: 240 x 160 x 9. Weight in Grams: 273.
The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are ... Read more
The mainstay of therapy for rheumatoid disease is the non-steroid antiinflammatory drugs (NSAIDs), despite their inherent gastrointestinal toxicity and ability to cause renal damage in susceptible patients. The theory that the beneficial and toxic effects of NSAIDs stem from a reduction in prostanoid production through inhibition of cyclooxygenase implied that particular toxicities were inevitable with NSAIDs and would always be correlated with efficacy. However, over the years, it became apparent that at therapeutic doses, some NSAIDs had greater toxic side-effects than others, a fact not explained by the general theory. A significant clarification arose from the discovery that there are ... Read more
Product Details
Format
Paperback
Publication date
2012
Publisher
Springer Netherlands
Number of pages
150
Condition
New
Number of Pages
150
Place of Publication
Dordrecht, Netherlands
ISBN
9789401060417
SKU
V9789401060417
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About . Ed(S): Vane, Sir John R.; Botting, Jack H.
Sir John Vane is the Director General at the William Harvey Research Institute, an independent charitable foundation within Queen Mary and Westfield College of the University of London, UK. Sir John Vane shared the Nobel Prize in Physiology or Medicine in 1982 for his discoveries of the mechanism of action of aspirin and of prostacyclin, as well as ... Read more
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