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Viral Proteins Counteracting Host Defenses
. Ed(S): Koszinowski, U. H.; Hengel, H.
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Description for Viral Proteins Counteracting Host Defenses
Paperback. Editor(s): Koszinowski, U. H.; Hengel, H. Series: Current Topics in Microbiology and Immunology. Num Pages: 336 pages, 4 colour illustrations, 5 black & white tables, biography. BIC Classification: MJCM; MMFM. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 19. Weight in Grams: 521.
Since the first observations of viral interference with antigen presentation in the MHC class-I pathway, the field has advanced to a detailed analysis. We know numerous genes and for some of them we have profound information on their mechanistic function. The antigen presentation pathway is affected at all stages starting from proteasomal degradation of an antigenic viral protein, as shown for EBV, transfer of the proteasomal cleavage products as peptides in the ER by specific transporters, the loading of the nascent MHC class-I molecule, and finally the transport of the complex to the surface and presentation in a normal or ... Read more
Since the first observations of viral interference with antigen presentation in the MHC class-I pathway, the field has advanced to a detailed analysis. We know numerous genes and for some of them we have profound information on their mechanistic function. The antigen presentation pathway is affected at all stages starting from proteasomal degradation of an antigenic viral protein, as shown for EBV, transfer of the proteasomal cleavage products as peptides in the ER by specific transporters, the loading of the nascent MHC class-I molecule, and finally the transport of the complex to the surface and presentation in a normal or ... Read more
Product Details
Format
Paperback
Publication date
2011
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Germany
Number of pages
336
Condition
New
Series
Current Topics in Microbiology and Immunology
Number of Pages
325
Place of Publication
Berlin, Germany
ISBN
9783642639746
SKU
V9783642639746
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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