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Improved Non-steroid Anti-inflammatory Drugs: COX-2 Enzyme Inhibitors
. Ed(S): Vane, Sir John R.; Botting, Jack H.; Botting, R.M.
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Description for Improved Non-steroid Anti-inflammatory Drugs: COX-2 Enzyme Inhibitors
Paperback. Editor(s): Vane, Sir John R.; Botting, Jack H.; Botting, R.M. Num Pages: 200 pages, biography. BIC Classification: MMG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 14. Weight in Grams: 405.
In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological ... Read more
In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological ... Read more
Product Details
Format
Paperback
Publication date
2011
Publisher
Springer Netherlands
Number of pages
200
Condition
New
Number of Pages
200
Place of Publication
Dordrecht, Netherlands
ISBN
9789401090315
SKU
V9789401090315
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About . Ed(S): Vane, Sir John R.; Botting, Jack H.; Botting, R.M.
Sir John Vane is the Director General at the William Harvey Research Institute, an independent charitable foundation within Queen Mary and Westfield College of the University of London, UK. Sir John Vane shared the Nobel Prize in Physiology or Medicine in 1982 for his discoveries of the mechanism of action of aspirin and of prostacyclin, as well as ... Read more
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