The book illustrates that the traditional philosophical concept of the "Universe”, the "World” has led to anomalies and paradoxes in the realm of knowledge. The author replaces this notion by the EDWs perspective, i.e. a new axiomatic hyperontological framework of Epistemologically Different Worlds” (EDWs). Thus it becomes possible to find a more appropriate approach to different branches of science, such as cognitive neuroscience, physics, biology and the philosophy of mind. The consequences are a better understanding of the mind-body problem, quantum physics non-locality or entanglement, the measurement problem, Einstein’s theory of relativity and the binding problem in cognitive neuroscience.