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Steroid Hormones and the T-cell Cytokine Profile
. Ed(S): Rook, Graham A. W.; Lightman, S.
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Description for Steroid Hormones and the T-cell Cytokine Profile
Paperback. Editor(s): Rook, Graham A. W.; Lightman, S. Num Pages: 227 pages, biography. BIC Classification: MFG; MJCM; MJG. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 12. Weight in Grams: 370.
The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ... Read more
The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ... Read more
Product Details
Format
Paperback
Publication date
2011
Publisher
Springer London Ltd United Kingdom
Number of pages
227
Condition
New
Number of Pages
227
Place of Publication
England, United Kingdom
ISBN
9781447112389
SKU
V9781447112389
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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