Orr, who has experienced panic attacks herself, kept a diary of her participation as a research subject in clinical trials for the Upjohn Company’s anti-anxiety drug Xanax. This “panic diary” grounds her study and suggests the complexity of her desire to track the diffusion and regulation of panic in U.S. society. Orr’s historical research, theoretical reflections, and biographical narrative combine in this remarkable and compelling genealogy, which documents the manipulation of panic by the media, the social sciences and psychiatry, the U.S. military and government, and transnational drug companies.