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The Epothilones. From Soil to the Clinic.
Johann H. . Ed(S): Mulzer
€ 194.05
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Description for The Epothilones. From Soil to the Clinic.
Paperback. Epothilones are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. Editor(s): Mulzer, Johann H. Series Editor(s): Kinghorn, A. Douglas. Series: Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Num Pages: 269 pages, biography. BIC Classification: MF; PNN; PSB; TCB; TDC. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 14. Weight in Grams: 421.
Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the ... Read more
Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the ... Read more
Product Details
Format
Paperback
Publication date
2010
Publisher
Springer Verlag GmbH Austria
Number of pages
269
Condition
New
Series
Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Prod
Number of Pages
260
Place of Publication
Vienna, Austria
ISBN
9783211999288
SKU
V9783211999288
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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