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Two-Hybrid Systems
Paul N. . Ed(S): Macdonald
€ 124.77
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Description for Two-Hybrid Systems
Hardback. Assembles a collection of molecular tools for examining and characterizing protein-protein, protein-DNA, and protein-RNA interactions. This work also provides methods for dealing with the problem of artifacts and false positives and for identifying the interacting partners in biological systems, including the SMAD and nuclear receptor pathways. Editor(s): MacDonald, Paul N. Series: Methods in Molecular Biology. Num Pages: 336 pages, biography. BIC Classification: PSA; PSD. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 155 x 20. Weight in Grams: 670.
Many, if not all, essential biological processes require selective interactions between proteins. Complex signaling systems require sequential, ordered protein-protein interactions at essentially all levels of the signaling cascade. For example, peptide hormones interact with selective membrane receptor proteins, and autophosphorylation of the receptor then recruits other key regulatory proteins that initiate kinase cascades in which each phosphorylation event requires selective recognition of the protein substrate. The ultimate signaling effect, in many cases, is the regulation of RNA polymerase II-directed transcr- tion in the nucleus, a process that involves numerous, multiprotein complexes important for transcription initiation, elongation, termination, and reinitiation. Defining, ... Read more
Many, if not all, essential biological processes require selective interactions between proteins. Complex signaling systems require sequential, ordered protein-protein interactions at essentially all levels of the signaling cascade. For example, peptide hormones interact with selective membrane receptor proteins, and autophosphorylation of the receptor then recruits other key regulatory proteins that initiate kinase cascades in which each phosphorylation event requires selective recognition of the protein substrate. The ultimate signaling effect, in many cases, is the regulation of RNA polymerase II-directed transcr- tion in the nucleus, a process that involves numerous, multiprotein complexes important for transcription initiation, elongation, termination, and reinitiation. Defining, ... Read more
Product Details
Format
Hardback
Publication date
2001
Publisher
Humana Press Inc. United States
Number of pages
336
Condition
New
Series
Methods in Molecular Biology
Number of Pages
336
Place of Publication
Totowa, NJ, United States
ISBN
9780896038325
SKU
V9780896038325
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
Reviews for Two-Hybrid Systems
"The utility of the technique makes this book worthwhile since all the information necessary to get started is included. Anyone should be able to start using the two-hybrid system in their lab using this book as a guide. The book is written for all levels of expertise from student to senior investigator. Each chapter is written by an expert in ... Read more