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Kosuke Ohsawa - Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer - 9784431554462 - V9784431554462
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Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer

€ 122.53
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Description for Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer Hardback. Series: Springer Theses. Num Pages: 122 pages, 70 black & white illustrations, 14 colour illustrations, 15 black & white tables, biograp. BIC Classification: MQP; PNN; PSB. Category: (G) General (US: Trade). Dimension: 235 x 155 x 8. Weight in Grams: 356.

This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a ... Read more

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Product Details

Format
Hardback
Publication date
2015
Publisher
Springer Verlag, Japan Japan
Number of pages
122
Condition
New
Series
Springer Theses
Number of Pages
109
Place of Publication
Tokyo, Japan
ISBN
9784431554462
SKU
V9784431554462
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15

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