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Trinucleotide Repeat Protocols
Yoshinori Kohwi
€ 129.35
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Description for Trinucleotide Repeat Protocols
Hardback. Describes techniques for studying trinucleotide pathology at the molecular level. This book features protocols covering targets ranging from DNA and RNA, to proteins and whole animals. It utilizes techniques, including gel electrophoresis, quantitative RT-PCR, and immunological analysis, antibody usage and its applications. Series: Methods in Molecular Biology. Num Pages: 342 pages, biography. BIC Classification: PSAK. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly; (UU) Undergraduate. Dimension: 235 x 155 x 20. Weight in Grams: 690.
Trinucleotide repeats are relatively common in the human genome. These simple repeats have received much attention since epoch-making discoveries were made that particular trinucleotide repeats are expanded in the causal genes of human hereditary neurological disorders. For example, the CGG repeat is expanded in fragile X syndrome at the 5' untranslated region (UTR) of its causal gene. In myotonic dystrophy, it is the CTG repeat that is expanded at the 3' UTR of its causal gene. The CAG repeat was also found expanded in coding regions of the genes responsible for X-linked spinal and bulbar muscular atrophy, Huntington’s disease, spinocerebellar ... Read more
Trinucleotide repeats are relatively common in the human genome. These simple repeats have received much attention since epoch-making discoveries were made that particular trinucleotide repeats are expanded in the causal genes of human hereditary neurological disorders. For example, the CGG repeat is expanded in fragile X syndrome at the 5' untranslated region (UTR) of its causal gene. In myotonic dystrophy, it is the CTG repeat that is expanded at the 3' UTR of its causal gene. The CAG repeat was also found expanded in coding regions of the genes responsible for X-linked spinal and bulbar muscular atrophy, Huntington’s disease, spinocerebellar ... Read more
Product Details
Format
Hardback
Publication date
2004
Publisher
Humana Press Inc. United States
Number of pages
342
Condition
New
Series
Methods in Molecular Biology
Number of Pages
342
Place of Publication
Totowa, NJ, United States
ISBN
9781588292438
SKU
V9781588292438
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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