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. Ed(S): Nathke, Inke S.; McCarthney, Brooke M. - APC Proteins - 9781441911445 - V9781441911445
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APC Proteins

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Description for APC Proteins Hardback. The Apc protein is a multifunctional participant in a diverse array of cellular functions. This book provides an overview of the functions performed by the Apc protein. Editor(s): Nathke, Inke S.; McCarthney, Brooke M. Series: Advances in Experimental Medicine and Biology. Num Pages: 148 pages, 22 black & white illustrations, 3 colour illustrations, 4 black & white tables, biography. BIC Classification: MBGR; PSBC. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 15. Weight in Grams: 408.
The initial identification of the Adenomatous polyposis eoli (Ape) gene as the site of mutations in familial adenomatous polyposis (FAP) was described in 1 1992. ,2 A causal relationship between Ape mutations and intestinal tract tumours was confirmed three years later with the establishment ofthe Min mouse model) These mice are heterozygous forApe and develop numerous intestinal tumours that mimic FAP. Subsequently, Ape has emerged as the most commonly mutated gene in colorectal cancerwith reports varying between 50-80% ofsporadic tumours car- rying such mutations. The search for how mutations in Ape initiate and/or support progression oftumours in the intestinal tract ... Read more

Product Details

Format
Hardback
Publication date
2009
Publisher
Springer-Verlag New York Inc. United States
Number of pages
148
Condition
New
Series
Advances in Experimental Medicine and Biology
Number of Pages
148
Place of Publication
New York, NY, United States
ISBN
9781441911445
SKU
V9781441911445
Shipping Time
Usually ships in 5 to 9 working days
Ref
99-3

About . Ed(S): Nathke, Inke S.; McCarthney, Brooke M.
Inke Näthke is the professor of Epithelial Biology at the University of Dundee. Her research interest is to determine how specific molecular changes produce changes in cells and ultimately in whole tissues during early stages of tumourigenesis. Her focus is on colorectal cancers but the common epithelial origin of most tumours makes this work relevant to many other organs. Her ... Read more

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