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Tetramer Stability and Functional Regulation of Tumor Suppressor Protein P53
Rui Kamada
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Description for Tetramer Stability and Functional Regulation of Tumor Suppressor Protein P53
Paperback. This book presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Series: Springer Theses. Num Pages: 88 pages, biography. BIC Classification: PSB; PSBC. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 5. Weight in Grams: 150.
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein–protein interactions, DNA binding, and the post-translational modification of p53. A small destabilization of the tetrameric structure therefore could result in dysfunction of tumor suppressor activity. This work ... Read more
This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of the mutant peptides varied widely. Formation of a tetrameric structure is to be critical for protein–protein interactions, DNA binding, and the post-translational modification of p53. A small destabilization of the tetrameric structure therefore could result in dysfunction of tumor suppressor activity. This work ... Read more
Product Details
Format
Paperback
Publication date
2014
Publisher
Springer Verlag, Japan Japan
Number of pages
88
Condition
New
Series
Springer Theses
Number of Pages
74
Place of Publication
Tokyo, Japan
ISBN
9784431547259
SKU
V9784431547259
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About Rui Kamada
Dr. Rui Kamada Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
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