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Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells
Iman Tavassoly
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Description for Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells
Hardback. Series: Springer Theses. Num Pages: 100 pages, 46 black & white illustrations, 1 colour illustrations, biography. BIC Classification: MJCL; PHVN; PSA; PSF; TGM. Category: (G) General (US: Trade). Dimension: 235 x 155 x 8. Weight in Grams: 327.
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental ... Read more
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental ... Read more
Product Details
Format
Hardback
Publication date
2015
Publisher
Springer International Publishing AG Switzerland
Number of pages
100
Condition
New
Series
Springer Theses
Number of Pages
79
Place of Publication
Cham, Switzerland
ISBN
9783319149615
SKU
V9783319149615
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About Iman Tavassoly
Iman Tavassoly (MD, PhD) is a physician-scientist working at Icahn School of Medicine at Mount Sinai and Systems Biology Center New York. His research interests include systems biology of complex diseases and cancer biology. He graduated from medical school in 2007 and received his PhD in Genetics, Bioinformatics and Computational Biology at Virginia Tech where he was awarded as the ... Read more
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