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Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities
Giovanni Melillo (Ed.)
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Description for Hypoxia and Cancer: Biological Implications and Therapeutic Opportunities
Hardback. Editor(s): Melillo, Giovanni. Series: Cancer Drug Discovery and Development. Num Pages: 377 pages, 17 black & white illustrations, 36 colour illustrations, biography. BIC Classification: MJCL; MMG; PSAK. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 25. Weight in Grams: 730.
The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem ... Read more
The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem ... Read more
Product Details
Publisher
Springer-Verlag New York Inc.
Format
Hardback
Publication date
2013
Series
Cancer Drug Discovery and Development
Condition
New
Weight
730g
Number of Pages
363
Place of Publication
New York, NY, United States
ISBN
9781461491668
SKU
V9781461491668
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
About Giovanni Melillo (Ed.)
Dr. Giovanni Melillo is the Medical Director for the branch of Discovery Medicine at Bristol-Myers Squibb. Prior to his role at BMS, he was the Senior Investigator and Head of the Tumor Hypoxia Lab at the Developmental Therapeutics Program of the National Cancer Institute. He's been investigating hypoxia and its role in tumor progression for over 15 years. He's currently ... Read more
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