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Chevret - Statistical Methods for Dose-finding experiments - 9780470861233 - V9780470861233
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Statistical Methods for Dose-finding experiments

€ 120.81
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Description for Statistical Methods for Dose-finding experiments Hardcover. Dose-finding in practice is often done very poorly; conventional methods, which are in widespread use, can be unreliable and lead to inaccurate results. However, there have been many advances in recent years, with new sophisticated statistical techniques being developed. It is important that these new techniques are utilized correctly. Editor(s): Chevret, Sylvie. Series: Statistics in Practice. Num Pages: 334 pages, black & white illustrations. BIC Classification: PB. Category: (P) Professional & Vocational. Dimension: 234 x 161 x 23. Weight in Grams: 596.

Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role in identifying optimal dosage. Used appropriately, these methods provide reliable results and reduce trial duration and costs. In practice, however, dose-finding is often done poorly, with widely used conventional methods frequently being unreliable, leading to inaccurate results. However, there have been many advances in recent years, with new statistical techniques being developed and it is important that these new techniques are utilized correctly.

Statistical Methods for Dose-Finding Experiments reviews the main statistical approaches for ... Read more

  • Includes an introductory section, summarizing the essential concepts in dose-finding.
  • Contains a section on algorithm-based approaches, such as the traditional 3+3 design, and a section on model-based approaches, such as the continual reassessment method.
  • Explains fundamental issues, such as how to stop trials early and how to cope with delayed or ordinal outcomes.
  • Discusses in detail the main websites and software used to implement the methods.
  • Features numerous worked examples making use of real data.

Statistical Methods for Dose-Finding Experiments is an important collaboration from the leading experts in the area. Primarily aimed at statisticians and clinicians working in clinical trials and medical research, there is also much to benefit graduate students of biostatistics.

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Product Details

Format
Hardback
Publication date
2006
Publisher
John Wiley & Sons Inc United Kingdom
Number of pages
334
Condition
New
Series
Statistics in Practice
Number of Pages
336
Place of Publication
New York, United States
ISBN
9780470861233
SKU
V9780470861233
Shipping Time
Usually ships in 7 to 11 working days
Ref
99-50

About Chevret
Sylvie Chevret, Hopital St Louis, Paris, France

Reviews for Statistical Methods for Dose-finding experiments
"This book is an important collaboration of leading experts in the area. Primarily aimed at statisticians and clinicians working in clinical trials and medical research, there is also much to benefit graduate students of biostatistics." (Zentralblatt MATH, 2011) "It represents a good investment and would be a useful addition to the pharmaceutical researcher's library." (Technometrics, August 2008) ... Read more

Goodreads reviews for Statistical Methods for Dose-finding experiments


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