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Metal Complex - DNA Interactions
Hadjiliadis
€ 198.02
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Description for Metal Complex - DNA Interactions
Hardback. Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine. Editor(s): Hadjiliadis, Nick D.; Sletten, Einar. Num Pages: 544 pages, Illustrations. BIC Classification: MFG; PN; PS. Category: (P) Professional & Vocational. Dimension: 248 x 172 x 37. Weight in Grams: 1076.
Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.
Metal ions and metal complexes have long been recognized as critically important components of nucleic acid chemistry, both in regulation of gene expression and as promising therapeutic agents. Understanding how metal complexes interact with DNA has become an active research area at the interface between chemistry, molecular biology and medicine.
Metal Complex - DNA Interactions provides a comprehensive overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity. The text is divided into four parts:
- Basic Structural and Kinetic Aspects: includes chapters on sequence-selective metal ... Read more
- Medical Applications: focuses on anticancer platinum drugs, including discussions on DNA repair in antitumor effects of platinum drugs and photo-dynamic therapy.
- DNA-Recognition - Nucleases and Sensor: describes probes for DNA recognition, artificial restriction agents, metallo-DNAzymes for metal sensing applications and metal ion dependent catalysis in nucleic acid enzymes.
- Toxicological Aspects: deals with structural studies of mercury–DNA interactions, chromium-induced DNA damage and repair, and the effect of arsenic and nickel on DNA integrity.
This book will be a valuable resource for academic researchers and professionals from a range of pharmaceutical and chemical industries, particularly those involved in the development of new and less toxic anticancer metallo-drugs, and in the field of environmental and toxicological chemistry.
Show LessProduct Details
Format
Hardback
Publication date
2009
Publisher
John Wiley and Sons Ltd United Kingdom
Number of pages
544
Condition
New
Number of Pages
544
Place of Publication
Hoboken, United Kingdom
ISBN
9781405176293
SKU
V9781405176293
Shipping Time
Usually ships in 7 to 11 working days
Ref
99-1
About Hadjiliadis
Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.
Reviews for Metal Complex - DNA Interactions
"An impressive overview of the great diversity of current research." (Angewandte Chemie International Edition, February 2010) "An essential part of the library for laboratories involved in bioinorganic and medicinal inorganic chemistry." (Chemistry World, September 2009)