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Molecular Mechanisms for Repair of DNA
Philip Courtland . Ed(S): Hanawalt
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Description for Molecular Mechanisms for Repair of DNA
Paperback. Editor(s): Hanawalt, Philip Courtland. Series: Basic Life Sciences. Num Pages: 425 pages, biography. BIC Classification: PSF; PSV. Category: (P) Professional & Vocational. Dimension: 234 x 156 x 22. Weight in Grams: 676.
The excision-repair of ultraviolet-induced lesions in DNA involves a recogni- tion and incision step which is followed by excision of the damaged material, DNA repair resynthesis, and sealing of the fmal gap by polynucleotide ligase (e.g. Howard-Flanders, 1968). The initial incision step appears to require an endo- nuclease which is absent in the uvrA and uvrR mutants of E. eoli K12 (Braun et al., Part A of this book). The polAl strains are deficient in DNA polymerase I activity (de Lucia and Cairns, 1969) and are partially deficient in repairing single-strand breaks in DNA (incision breaks) produced by the excision-repair ... Read more
The excision-repair of ultraviolet-induced lesions in DNA involves a recogni- tion and incision step which is followed by excision of the damaged material, DNA repair resynthesis, and sealing of the fmal gap by polynucleotide ligase (e.g. Howard-Flanders, 1968). The initial incision step appears to require an endo- nuclease which is absent in the uvrA and uvrR mutants of E. eoli K12 (Braun et al., Part A of this book). The polAl strains are deficient in DNA polymerase I activity (de Lucia and Cairns, 1969) and are partially deficient in repairing single-strand breaks in DNA (incision breaks) produced by the excision-repair ... Read more
Product Details
Format
Paperback
Publication date
2012
Publisher
Springer-Verlag New York Inc. United States
Number of pages
425
Condition
New
Series
Basic Life Sciences
Number of Pages
425
Place of Publication
New York, NY, United States
ISBN
9781468429008
SKU
V9781468429008
Shipping Time
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Ref
99-15
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