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NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens: A Novel NMR-Tool for Natural Product Detection
Martin Lorenz Stein
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Description for NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens: A Novel NMR-Tool for Natural Product Detection
hardcover. Series: Springer Theses. Num Pages: 87 pages, 4 black & white illustrations, 24 colour illustrations, biography. BIC Classification: PNFS; PSB. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 10. Weight in Grams: 249.
Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core ... Read more
Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core ... Read more
Product Details
Format
Hardback
Publication date
2014
Publisher
Springer Switzerland
Number of pages
87
Condition
New
Series
Springer Theses
Number of Pages
71
Place of Publication
Cham, Switzerland
ISBN
9783319079134
SKU
V9783319079134
Shipping Time
Usually ships in 15 to 20 working days
Ref
99-15
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